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d-Allulose Inhibits Ghrelin-Responsive, Glucose-Sensitive and Neuropeptide Y Neurons in the Arcuate Nucleus and Central Injection Suppresses Appetite-Associated Food Intake in Mice
doi: 10.1093/bfgp/elw017 125 ZadehFJAkbariTZayeriZDSamimiADavariNRezaeeyanH
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Strategies for successful discontinuation include: Gradual dose tapering rather than abrupt cessation (e.g., reduce by 2.5 mg every 4-6 weeks) Establishing sustainable eating habits while on medication, before you stop Building consistent exercise routines that persist independently of medication Working with a dietitian or nutritionist during the transition period Monitoring weight weekly and having a clear plan for intervention if regain exceeds a defined threshold Some providers recommend transitioning from tirzepatide to a lower-dose GLP-1 maintenance protocol, or cycling on and off at intervals
Many people experience a two to four week period during the medication transition where weight loss stalls or they regain two to five pounds
