2013 Jun;24(6):310-9
Latin America Market Insight : Growing awareness of fitness and affordable nutrition sustains supplement market expansion

Contact your healthcare provider promptly if you experience: Severe or persistent heartburn unresponsive to over-the-counter antacids or lifestyle modifications Difficulty swallowing (dysphagia) or painful swallowing (odynophagia), which may indicate esophageal inflammation or stricture Persistent nausea and vomiting that prevents adequate oral intake or leads to dehydration Vomiting blood (hematemesis) or material resembling coffee grounds Black, tarry stools (melena) or visible blood in stool Severe abdominal pain, particularly if localized to the upper abdomen or radiating to the back (stop medication immediately if pancreatitis is suspected) Right upper quadrant pain, fever, or yellowing of skin/eyes, which may indicate gallbladder disease Unintentional weight loss beyond expected therapeutic effects New or worsening chest pain (call 911 if concerning for heart attack), especially if accompanied by shortness of breath These symptoms may indicate complications such as erosive esophagitis, gastrointestinal bleeding, pancreatitis, or gastroparesis

Lets look closer at two of those: changes in hormones (think menopause) and popular medications like GLP-1s (such as semaglutide or tirzepatide)
It belongs to a class of medicines called GLP-1 receptor agonists drugs that work by mimicking a gut hormone your body makes naturally
Evidence for Liver Benefits GLP-1 medications produce meaningful liver improvements: Reduced liver fat: Studies using imaging show significant reductions in liver fat content with semaglutide and other GLP-1 medications