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High temperatures during shipping or prolonged storage above recommended conditions can cause irreversible aggregation
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The gradual titration protocol exists specifically to manage this
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The generic GLP-1 approval from the US Food and Drug Administration (FDA) is for Teva Pharmaceuticals version of Novo Nordisks injectable Saxenda (liraglutide)
Saxenda was also noted to cause hypoglycemia (low blood sugar) when used with some other anti-diabetic drugs (sulfonylureas)
doi:10.1073/pnas.72.4.1349
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