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However, potential adverse mental health effects have also been reported and require vigilance: Nausea and gastrointestinal symptoms , common side effects of GLP-1 medications, may increase anxiety in susceptible individuals Rapid weight loss can occasionally trigger psychological distress or exacerbate eating disorder behaviours Mood changes , including low mood, have been reported in post-marketing surveillance, though causality remains uncertain Some patients report feeling emotionally flat or detached , though this is anecdotal and not well characterised in clinical trials The Summary of Product Characteristics (SmPC) for GLP-1 receptor agonists used for weight management (such as Saxenda and Wegovy) includes specific warnings about monitoring for mood disorders and suicidal thoughts
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Funding acquisition, WL, YYZ, and ML
Once cartilage is significantly eroded and bony changes have occurred, peptides cannot regenerate the joint surface
Obesity , 22(S1), S50S59
Another serious but less common cause is a condition known as Small Intestinal Bacterial Overgrowth (SIBO)
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