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This substitution, combined with albumin binding via a C18 fatty diacid, is what extends its circulating half-life relative to the native hormone
The body adapts more gradually
Some people notice changes faster than others
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[5] Steady-state drug levelswhen the medication reaches consistent concentrations in your bodyvary by product: liraglutide reaches steady state in approximately 2-3 days, while weekly formulations like semaglutide take 4-5 weeks and dulaglutide about 2-4 weeks at any given dose
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