Decision factors: Weight loss goals: Want maximum weight loss and can tolerate side effects: Tirzepatide (Zepbound) shows ~4% greater weight loss than semaglutide on average Want proven cardiovascular benefits: Semaglutide has demonstrated 20% reduction in major cardiovascular events in the SELECT trial Want to try oral option: Oral semaglutide (Rybelsus) for diabetes, though weight loss is less than injectable Side effect sensitivity: Some people tolerate one better than the other
H.KwakC.YouD.et al (2023)
Despite their effectiveness, concerns remain regarding safety, tolerability and potential health risks, as well as the need for long-term administration and the subsequent cost
The most frequently studied biomarkers include: carbonylated and/or glycosylated proteins, lipid peroxidation and DNA damage (Shibata et al., 2002)
Get emergency help if you have dark tarry stools and severe pain, fainting, or signs of shock
As more research emerges and more data becomes available, guidelines will continue to evolve