They both come in six different doses, with new patients starting on the lowest dose and gradually working their way up, and have similar potential side effects, which tend to be mild gastrointestinal issues.
Prostaglandins Leukot.Essent.Fatty Acids 2002;67(1):33-38
Healthcare providers often increase, decrease, add, or exclude certain vitamins and minerals to create a focused treatment for their patients specific goals
Both diarrhea (33.3% at 12 mg) and constipation (16.7% at 12 mg) were reported in Phase 2, and both can produce lower abdominal cramping through different mechanisms researchers sometimes describe this presentation as retatrutide gas pain or trapped-gas-style pressure rather than classic stomach cramps
Patients may experience nausea, diarrhea, abdominal pain, constipation, or vomiting until their body becomes more accustomed to their medications
While B12 shots are typically safe and well-tolerated, it is possible for some individuals to encounter minor side effects such as temporary redness or bruising at the injection site, which typically subsides promptly