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Hyperimmune activation and autoimmunity are considered as potential causative factors in the onset of PASC 225

Rabbit knee joint tissues were fixed in 4% paraformaldehyde for 16 h, dehydrated with graded concentrations of ethanol, and embedded in paraffin

Jun 2013;36(6):1454-1461

More specifically speaking, the mechanism potentially involved downregulation of macrophage CD11b, which played a vital role in monocyte adhesion, as well as decreased expression of macrophage modulators including CXCL-10, CXCL-1, C-C motif chemokine ligand-1 (CCL-2) and tissue inhibitor of metal protease-1 (TIMP-1) (Robinson et al., 2015)

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These guidelines are the foundation for safe and effective research protocols using these compounds