Weight comes back after stopping: in the STEP 1 extension, people regained about two-thirds of their lost weight within a year of stopping (Wilding and colleagues, Diabetes, Obesity and Metabolism , 2022)
Int J Infect Dis 100:483489 Winarski KL, Tang J, Klenow L et al (2019) Antibody-dependent enhancement of influenza disease promoted by increase in hemagglutinin stem flexibility and virus fusion kinetics
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This medication is not appropriate for individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), or those who are pregnant or breastfeeding
For a 50-pound goal, that translates to 25 to 50 weeks of treatment at therapeutic dose, plus the escalation period