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Dosing starts at 0.25 mg weekly and increases to 0.5 mg weekly after one month, up to a maximum dose of 2 mg weekly
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Some individuals benefit from split-dosing strategies, taking smaller amounts of collagen twice daily
11,12 This model proposes that the RBD-PD subtype follows a body-first trajectory, in which -synuclein pathology originates in the peripheral or enteric nervous system (ENS) and subsequently ascends via the vagus nerve to the brainstem, particularly the locus coeruleus/subcoeruleus complex, which is considered one of the core pathological nuclei involved in RBD
While these results provide a robust basis for investigating GLP-1 agonist use in SUDs, there are some potential drawbacks that should be weighed
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