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In a study involving 2,000 obese adults, participants who took GLP-1 Treatments, Semaglutide or Tirzepatide while adhering to a diet and exercise regimen experienced significantly greater weight loss than those who relied solely on lifestyle adjustments

Novo Nordisk has also cited indirect comparison data suggesting that fewer patients discontinued oral semaglutide due to side effects compared with orforglipron, though the companies and independent commentators note the significant methodological limitations of such comparisons in the absence of a head-to-head obesity trial

Romanian Biotechnological Letters, 25 (6), 2132-2139

What Is GLP-1 and Why Does It Matter

FDA-approved medications have gone through extensive clinical trials establishing safety and efficacy across diverse populations

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