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6.4 Neuroprotective role of GLP-1 The neuroprotective effects of GLP-1 receptor agonists are receiving increasing attention in the context of sepsis, as GLP-1 can cross the bloodbrain barrier and act directly on the central nervous system

For instance, in vitro studies using HepG2 cells treated with palmitic acid revealed that the GLP-1RA exendin-4 downregulated the expression of SREBP-1c and FAS, thereby attenuating steatosis ( de novo lipogenesis ( In summary, GLP-1 receptor agonists regulate hepatic lipid metabolism in MASLD through activation of AMPK-mediated fatty acid -oxidation, suppressing lipogenesis-related gene expression, and enhancing lipid export and autophagy

Results of a qualitative study, published in JAMA Network Open , suggest that people using glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are aware that the drugs are not a standalone treatment for overweight and obesity, but their use may help push them towards making more sustainable lifestyle changes provided there is adequate and standardised clinical support throughout their treatment journey

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They need to be metabolized to work, Dr

Reactive oxygen species and the free radical theory of aging