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Starting Dose 0.3 mg In the phase 2 weight study, dosing started low at 0.3 mg weekly and was raised every 2 weeks to reduce nausea [1]

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It is worth noting that dysregulation of DNA methylation patterns has been linked to various brain disorders, including depression, anxiety, and cognitive decline (reviewed in: 14,15 )

SAMe is a methyl donor involved in various methylation reactions in the body, including the synthesis of some neurotransmitters, such as dopamine and serotonin

That makes it a useful reference compound in this area of study