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In these STEP trials, most participants experienced mild to moderate symptoms, with the incidence of severe side effects being 9.8% in the semaglutide treatment group and 6.4% in the placebo group
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It is characterized by progressive biliary inflammation and fibrosis, often leading to cirrhosis, portal hypertension, and liver failure, with liver transplantation remaining the only life-prolonging treatment for advanced cases 59,60