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Hsieh MJ, Liu HT, Wang CN, Huang HY, Lin Y, Ko YS, Wang JS, Chang VH, Pang JS

by binding to Apaf-1, HSP70 induces conformational changes that mask the procaspase-9-binding site on Apaf-1, thereby preventing procaspase-9 recruitment to the apoptosome and inhibiting downstream caspase activation (Beere et al., 2000)

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When methylation and energy metabolism are aligned, ATP production stabilizes, oxidative stress declines, and cognitive and behavioral symptoms often improve