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The regulatory read Randomized, double-blind, placebo-controlled Co-primary endpoints: PASI 75 + sPGA 0/1 at Week 16 (standard registration bar) Protocol aligned with both FDA and EMA de-risks a dual US/EU submission path Accrual continues toward ~705 total participants Read this as a milestone, not a signal
More aggressive protocols may use 3-5mg
Its role as an NNMT inhibitor highlights effects on metabolic function, endurance, and healthy aging
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Ohnishi, T
Medical and Pregnancy Considerations Pregnant or breastfeeding
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