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Denmark provides an excellent example of how this can be done ( Reference Rasmussen, Carle and Jorgensen 33 )

The oxidation of fatty acids generates heat as a metabolic byproduct

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Liver fat reduction In a substudy of the obesity trial, participants treated with retatrutide 8mg and 12mg showed dramatic reductions in liver fat content

Second, the majority of our studies were acute in nature and carried out in mice without chronic hyperglycemia, limiting the extrapolation of our data to settings using chronic administration of DPP4i in diabetic mice