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Nrf2 activation regulates antioxidant responses to modify cellular redox states from predominantly pro-oxidant to antioxidant, and, in an antioxidant environment, macrophage phenotypes shift from M1 pro-inflammatory to M2 anti-inflammatory, reducing the probability of cytokine storms, ARDS, and lethality (Tan et al., 2016

It has also been shown to decrease oxidative stress in the eye and delay age-related changes, including loss of visual acuity and the incidence of cataracts [12]

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S-palmitoylation plays crucial roles in the initiation, amplification, and termination of apoptotic signaling by precisely regulating the stability, membrane localization, and protein interactions of key proteins involved [59]

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