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NICE recommends GLP-1 therapy for type 2 diabetes (NG28) when: HbA1c remains elevated despite dual therapy with metformin and another oral agent The patient has a BMI of 35 kg/m or higher (or lower thresholds for certain ethnic groups) Significant weight loss would benefit other obesity-related comorbidities Insulin therapy poses specific risks or is declined by the patient For weight management, NICE has approved specific GLP-1 receptor agonists through Technology Appraisals
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355 However, due to our lack of understanding of exosome biology, structure, and biogenesis, the strategy of endogenous drug loading still requires further research and optimization
This vicious cycle of oxidative stress, mitochondrial damage, and energy hoarding is the biological reality behind the debilitating crashes seen in these conditions
The primary source of GLP-1 secretion in the body is the gut
Ozempic is covered for type 2 diabetes, a near-universal benefit
