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Glutaredoxin 2 knockout increases sensitivity to oxidative stress in mouse lens epithelial cells
GSH depletion triggered by the Nrf2/ATF3/4/ChaC1 pathway appears to be the primary factor inducing death in drug-resistant tumor cells (138), positioning ChaC1 as a key target for certain potential anti-tumor drugs such as busatol (139) and glaucocalyxin A (140)
Neurotherapeutics 18 , 252264 (2021)
S.Al-SulaitiH.et al
falciparum (PfTrxR, with an N-terminal 6-His tag was synthesized and inserted into pET15b (GenScript) and expressed in BL21 (DE3) cells and purified as described for human GR 20
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