Hypoglossal nerve stimulation therapy is approved by the Food and Drug Administration (FDA) and has been in clinical use since 2014 [45], with recent advances including the FDA approval of bilateral hypoglossal nerve stimulation [46], and ongoing investigations on targeted hypoglossal nerve stimulation [47, 48]
However, the fact that AOXs are largely available over-the-counter with a reasonable price increases the risk that some patients can overmedicate with AOXs leading to detrimental effects
[2] Side effects may include facial flushing, nausea and erection in males
Key benefits are: Sebum Regulation: Facilitates the uptake of fatty acids into mitochondria, where they are converted into energy rather than sebum, effectively reducing excess sebum production
Patten JL, Johns DR, Valle D, Eil C, Gruppuso PA, Steele G, Smallwood PM, Levine MA
Disturbed sleep