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This mechanism can lead to functional hypothalamic amenorrhoea if weight loss is rapid or energy intake is inadequate

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Additionally, the development of oral GLP-1 therapeutics opens up avenues for addressing comorbidities associated with obesity and type 2 diabetes, such as cardiovascular diseases and fatty liver disease

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Retatrutide (Eli Lilly), a triagonist currently in phase III clinical trials (TRIUMPH-1 NCT05929066 and others 3 ) adds a glucagon receptor agonist to its mechanism of action, promising an even greater impact on weight loss