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Results In this cohort study of 125,474 adults (mean [SD] age, 54.4 [13.1] years

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Gallstones, inflammation, or other gallbladder problems may cause symptoms such as severe abdominal pain, nausea, vomiting, and bloating

Side effects are similar regardless of age: primarily gastrointestinal (nausea, constipation, diarrhea)

Alternative satiety hormones such as PYY and NPY2 agonists show medium-to-high activity, with patents from major players [30, 31] and scientific reviews exploring their potential as complements or alternatives to GLP-1 [32]