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These benefits are now also evident in people with obesity at high CVD risk (or with known vascular disease) but without T2D, as shown by the favorable effects of semaglutide in the Semaglutide Effects on Heart Disease and Stroke in Patients with Overweight or Obesity (SELECT) clinical trial 36
It much more complicated than that
GLP-1-class receptor effects on satiety wane rapidly without continued dosing
However, it is unclear whether this growth could cause cancer or exacerbate existing tumors
The GLP-1 receptor is present in several areas of the brain involved in appetite regulation, so patients who are on the medication tend to feel full with smaller portions and do not feel the constant nagging of food chatter that drives people to snack during the day
In animal studies, peptide exposure was linked with increased fibroblast activity, suggesting potential roles in connective tissue processes
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