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10.1210/en.2009-1197
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Summary GLP-1R agonists appear to perform favorably compared with other approved pharmacological agents for pediatric obesity
however, compounded drugs are not FDA-approved, and their safety and efficacy are not validated
Despite the accumulating evidence around pathways engaged by the GLP-1R and other GPCRs in target tissues, there is still substantial uncertainty about the precise molecular mechanisms involved, particularly with regards to the spatiotemporal organisation of their signalling and their presence in spatially restricted subcellular (or even suborganelle) signalling hubs or nanodomains 61
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