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Autoimmune conditions like polymyalgia rheumatica or inflammatory myopathies can be unmasked by metabolic changes or weight loss
The 48 week trial data represents the full evolution of these benefits, with most meaningful changes appearing after 12-24 weeks of consistent treatment
Retatrutides broader trial program has reported additional findings beyond weight loss: the TRIUMPH-4 trial recorded meaningful reductions in knee osteoarthritis pain among participants with obesity, and a nested substudy of TRIUMPH-1 reported a 60.6% reduction in the apnea-hypopnea index in participants with obstructive sleep apnea
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