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For example, CTLA-4, an inhibitory receptor expressed primarily by T cells, dampens T-cell activity and is upregulated upon T-cell activation 84,85

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Congenital leptin deficiency: diagnosis and effects of leptin replacement therapy

Constipation Some researchers experience the opposite problem

The cause of the osmotic diarrhea prevents proper water and electrolyte absorption, according to Cleveland Clinic

That is the language FDA's reviewers and the committee will be testing the evidence against