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The DAC modification significantly prolongs the half-life of the peptide, providing more consistent stimulation of GH release. Teichman et al., Journal of Clinical Endocrinology & Metabolism Modified GRF (1-29) aka CJC-1295 without DAC: This shorter-acting version has a half-life of 30 minutes to 2 hours , mimicking natural GH pulses more closely

Dimova, S., Hoet, P

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While cagrilintide shows promise as a weight loss treatment, it's essential to understand who can safely use this medication

Pauwels, F., Vergauwen, B., Vanrobaeys, F., Devreese, B

Yet GLP-1 agonists have a ceiling