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The causes can be broadly categorised into exogenous (external) and endogenous (internal) factors, with the latter being of greater clinical significance

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Importantly, these changes in mitochondrial mass are not related to engagement of apoptosis: inhibition of caspase activity using zVAD-fmk did not prevent increases in mitochondrial abundance per cell (Extended Data Fig

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In the dulaglutide in REWIND and albiglutide in HARMONY studies, significant reductions in HbA1c levels were demonstrated