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In addition, nanoemulsions SSB-NMs co-delivered with TGF- inhibitors and selenocysteine (SeC) can effectively inhibit TGF-/TGF- RI/Smad2/3 signaling thereby stimulating the expression of NKC2D on NK92 cells and NKG2DL on tumor cells and significantly improving the lytic capacity of NK92 cells and promoting the immune response (94)
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Intracellular production of OH from H 2 O 2 is driven by the Fenton reaction, shown in Reaction 3 (43, 44, 48): As the most reactive known ROS, OH reacts with nearly all intracellular building blocks and macromolecules (amino acids, nucleic acids, phospholipids, sugars, proteins, RNA, DNA, lipids, polysaccharides)