Cardiovascular side effects with semaglutide are generally mild, and the SELECT trial demonstrated a 20% reduction in major adverse cardiovascular events (MACE) in people with established heart disease
Together, they create an environment where the body can adapt to changing composition with minimal visible or functional degradation
The research has been published in the New England Journal of Medicine .
In addition to affecting the host immune response, GM also affects cardiac function through the production of various metabolites
Eisenberg T, Knauer H, Schauer A, Bttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Frhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F (2009) Induction of autophagy by spermidine promotes longevity
CagriSema is two separate peptides, semaglutide and cagrilintide, combined in one injection.