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sTREM2 is thought to be protective by (i) stimulating microglial recruitment, activation, and phagocytosis of A (ii) inhibiting secondary nucleation of A fibrillization and preventing neurotoxicity, (iii) binding of sTREM2 to fibrils to enhance microglial uptake of fibrillar A
Tirzepatide works for weight loss mainly by reducing appetite, but it also improves insulin sensitivity and slows gastric emptying, making you feel fuller after meals
For weight loss specifically, the rate runs higher still, because the queries are information-seeking rather than transactional
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