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Patients with type 2 diabetes are already at increased risk of developing gastroparesis due to chronic hyperglycaemia affecting the vagus nerve
When administered therapeutically, GLP-1 receptor agonists work through several mechanisms: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner [1] [4] Suppressing glucagon release from alpha cells, reducing hepatic glucose output Slowing gastric emptying , which helps moderate post-meal blood glucose rises Promoting satiety through central nervous system pathways, potentially supporting weight reduction Investigational transdermal GLP-1 delivery systems typically utilise specialised technologies such as microneedles or active delivery methods rather than conventional patches, as GLP-1 molecules are large peptides that do not easily penetrate the skin barrier
& Krammer, F
Yes, they do and not just for weight loss, although the data on that is quite good
Use of antihyperglycemic drugs and risk of cancer in patients with diabetes
