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The elevated SOD2 activity is achieved as a result of an upregulation of sirtuin 3 (SIRT3), one member of a family of epigenetic enzymes located primarily in the mitochondrial matrix that regulates a variety of metabolic processes (104, 105)
Bupleurum comprises saponins, flavonoids, monoterpene glycosides, as well as coumarins and lignins as its chemical constituents
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For many patients, these effects tend to diminish over time with continued treatment
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