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These preclinical observations in rodents promote continued study with the aim of translation to larger animals and specifically primates, the central focus being the quantification of therapeutic index when administered for sustained periods
Mark Gold, psichiatra presso la Washington University School of Medicine, sottolinea limportanza di riconsiderare luso diffuso di questi farmaci, invitando le agenzie regolatorie a esaminare attentamente i risultati dello studio in merito alletichettatura e al monitoraggio di tali trattamenti
The monitoring parameters of pharmacotherapy with a narrow index also warrant consideration (for example, concurrent warfarin may require closer international normalized ratio monitoring)
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Except for ELIXA and EXSCEL [56, 59], all other major CVOTs point towards cardiovascular benefits of GLP-1RAs [53, 54, 61, 63, 66,67,68]
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