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While oral glutathione is generally considered to be safe, there is not enough data to recommend long-term use, especially for women who are pregnant or breastfeeding, people who take prescription or over-the-counter drugs, and those who have chronic conditions, says Malhotra

Bedmar EJ, Robles EF, Delgado MJ

That removes the most common escape hatch they just didnt use enough and leaves the more uncomfortable possibility that the original effect was smaller than reported, or absent

1986 Jan 15;261(2):928-33