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Most gut peptide research has been conducted in rodent models, and while the mechanistic data is compelling, translation to human outcomes has not been established through large clinical trials
Pickart and Margolina (2018) review documents broad gene-expression effects in vitro
Adipocyte Models Adipocyte differentiation, intracellular metabolite, and lipid-related preclinical assays
His published conclusion was that the compound should be treated as investigational
Patients with active malignancies, pregnancy, or significant hormonal imbalances should not use investigational peptides without specialist clearance