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Per ADA 2026 Standards of Care, patients with presymptomatic Type 1 DM (stage 12) may be identified by autoantibody screening before frank hyperglycemia occurs

Thanks The Nice guidelines are for NHS prescriptions and based on cost saving re hydroxocobalamin as it was costed in the 1980's

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Metabolic pathways: B12 is a cofactor in two critical reactions: Methylmalonyl-CoA mutase: Converts methylmalonyl CoA (from odd-chain fatty acids and some amino acids) into succinyl-CoA, which enters the Krebs (TCA) cycle to make ATP (cellular energy)

Research in animal models has measured new blood vessel growth, how tendon cells move and spread, and how tissue repairs after injury

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