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Weeks 2-4 - Gradual improvements in how your body handles fat

Aminoglycosides, tetracyclines, and certain other antibiotics may alter gut microbiota composition, potentially affecting the small amount of vitamin B12 that is produced by colonic bacteria, though this is generally not clinically significant for patients receiving injectable B12 supplementation

So what does science say about it

Serious Health Concerns: While rare, GLP1's can lead to severe conditions like acute pancreatitis, acute kidney injury, and gallbladder disease

Bedtime dosing works well because sleep represents a natural fasted state

You want to be sure the B12 gets into the body, says Green