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Particularly noteworthy is that FOXO4 influences not only lifespan but also the quality of aging through its interaction with the protein p53commonly referred to as the "guardian of the genome." This interaction regulates whether cells remain in a senescent, metabolically inactive state or undergo programmed cell death (apoptosis)

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Furthermore, Glu235 is located on a small alpha-helical unit which is preceded by a small loop and, therefore, the position of Glu235 might not be sufficiently stable

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