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They are different tools that address different things, so it is not a simple safer-or-not comparison

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Biochim Biophys Acta BBA Enzymol 250(3):459477 Landau B, Singer R, Klein T, Segenreich E (1978) Folic acid levels in blood and seminal plasma of normo- and oligospermic patients prior and following folic acid treatment

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On P38, blood cells from rats with 12 h-fasting were collected before and after 1 h of oral 2 g/kg glucose challenge