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To access data, the research proposal must be approved by the Scientific Advisory Committee of the Estonian Biobank as well as by the Estonian Committee on Bioethics and Human Research
Strikingly, the study revealed that the immune cells of these patients act as an "energy sink." In a desperate attempt to survive the overwhelming oxidative stress, the immune cells upregulate their own intracellular glutathione production
Crucially, this study shifted the scientific paradigm from a simple model of "glutathione depletion" to a model of an "overwhelmed compensatory mechanism." The discovery that circulating immune cells in these patients actually have elevated glutathione levelswhile simultaneously suffering from a severe depletion of other protective enzymes like SOD2revealed that the cells are desperately, and unsuccessfully, trying to fight off a catastrophic level of oxidative damage
The fact that GHK-Cu not only stimulates the production of dermal components, but also regulates their breakdown suggests that it should be used with caution
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