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The mechanism involves the suppression of pro-inflammatory chemokine (C-C motif) ligand 20 (CCL20), which is of significant importance in the Th17 immune response, as well as IL-33, which is a key cytokine associated with Th2 immune responses [224]
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In line with this finding, the inclusion of a DPP4 blocker alongside metformin led to a greater rise in GLP-1 levels, indicating synergistic and overlapping impacts, implying distinct modes of action for each drug (Migoya et al., 2010)
Phytomedicine 140 , 156633 (2025)
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