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The review found only four trials comparing CHCs with placebo, of which only one followed patients for over a year (238), whilst the remaining three followed weight changes over only 6-9 cycles

These mechanisms typically lead to significant weight loss over weeks to months

doi:10.1001/jamainternmed.2016.1522

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Ozempic and Mounjaro, however, are FDA-approved to manage diabetes, but due to their significant effectiveness in weight loss, they are commonly prescribed off-label to manage obesity