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But patients with sleep apnea may benefit more from tirzepatide. If you only have a modest amount of weight to lose, Holmes says semaglutide might be the first choice as its the gold standard with more long-term, established clinical data

GLP-1 agonists like semaglutide mimic a natural hormone called GLP-1 that regulates appetite and glucose levels in the body, which can help manage obesity and promote weight loss

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and based on notoriously imprecise diagnostic code data, not joint-specific symptom measurements