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The primary outcome was defined as MACE
Adults may generally qualify if they have a BMI of 30 or higher, which meets the medical definition of obesity, or a BMI of 27 or higher with at least one weight-related medical condition
BMI is a ratio of weight to height
No evidence supports dose adjustment based on alcohol consumption
The EFSA notes, The inherent uncertainty of this [factorial] approach is reflected in the wide range of cobalamin intake calculated to compensate for estimated daily losses, depending on the assumptions taken (EFSA, 2015). Appendix D
Starting with lower doses and gradually increasing helps minimize these effects
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