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Wegovy makes more sense if you want a medication with established regulatory approval and years of real-world safety data behind it
A Practical Analogy Semaglutide does not hold your hand at the dinner table
How These Peptides Support Mental Wellness Each peptide works in unique ways to support your brain and mood, but they share some common mechanisms: Enhanced Neuroplasticity : By promoting the growth and connectivity of neurons, these peptides improve your brains ability to adapt, learn, and perform
Am J Physiol-Endocrinol Metab
doi: 10.1210/jcem.82.5.3943
NICE Technology Appraisal guidance (TA875 for semaglutide/Wegovy and TA664 for liraglutide/Saxenda) recommends these medications for weight management in adults with: A body mass index (BMI) of at least 35 kg/m and At least one weight-related comorbidity (such as type 2 diabetes, hypertension, dyslipidaemia, obstructive sleep apnoea, or non-alcoholic fatty liver disease) For liraglutide (Saxenda), NICE TA664 specifies additional criteria including prediabetes (HbA1c 42-47 mmol/mol or fasting plasma glucose 5.5-6.9 mmol/L) or high risk of cardiovascular disease
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