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It is not safe for people who have: A seizure disorder or a history of seizures A history of anorexia or bulimia Opioid dependence or have recently used opioids Uncontrolled high blood pressure A history of suicidal thoughts or actions Are taking MAO inhibitors (certain antidepressants) If you have any of these conditions, talk to your doctor before starting Contrave, as it could increase the risk of serious side effects