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A Cochrane review from 2013 pooled data from six RCTs of NAC or carbocysteine (another mucolytic) in children with respiratory infections and found some benefit, although it was deemed to be of limited clinical relevance

The next decision point is PCACs recommendation after the July 2324, 2026 meeting

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Exposure to greater than 25 mg may precipitate a hypertensive crisis , marked by a rapid rise in blood pressure (often exceeding 180/120 mmHg), chest pain, and acute confusion

Start at 4 units (1 mg) for the first 15 days, then step up to 8 units (2 mg) at Day 16