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The reviews analysis confirms that synthetic GLP-1 medications like semaglutide and tirzepatide, originally developed to control blood sugar, offer clinically validated protection against cardiovascular disease (CVD), chronic kidney disease (CKD), and metabolic dysfunction-associated steatotic liver disease (MASLD)-related outcomes, including improvements in steatosis and fibrosis-related endpoints

When activated, these medications suppress the local production of $TNF-\alpha$ and $IL-6$ directly inside visceral fat cells, silencing the "cytokine storm" at its secondary source

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Le Prell et al., 2007a

Patients may underestimate the importance of concurrent lifestyle changes that could minimize muscle loss

Quick Answer: Wegovy and Prozac can generally be taken together safely under medical supervision, as they work through different mechanisms with no absolute contraindication to concurrent use